2L Smallest Oxygen Machine for Students and Business People

For students and business people who have been in high-intensity brain activities for a long time, the essence of brain fatigue is the imbalance between supply and demand of neurons. The core logic of our oxygen generator to alleviate brain fatigue is to accurately replenish the oxygen supply gap and repair the metabolic basis of the efficient operation of the brain. Its mechanism of action can be analyzed layer by layer from the particularity of brain oxygen metabolism and the molecular mechanism of fatigue occurrence to the precise path of oxygen supplementation intervention:

Brain: the most “picky” “oxygen-consuming organ” in the human body. Hypoxia triggers a metabolic crisis

The brain accounts for only 2% of the body weight, but it consumes 20%-25% of the body’s oxygen (about 50ml/min). This “hyperoxygen demand” comes from the special metabolic properties of neurons:

• As electrically active cells, neurons rely on the transmembrane transport of sodium ions (Na⁺) and potassium ions (K⁺) as electrically active cells, and the “sodium-potassium pump” that maintains this ion gradient can pump 3 Na⁺ and 2 K⁺ for every molecule of ATP consumed, and its energy consumption accounts for more than 50% of the total brain energy consumption;
• More importantly, neurons have almost no “anaerobic reserve”: Unlike muscle cells that can quickly supply energy through anaerobic glycolysis, neurons’ glucose metabolism is 95% dependent on aerobic oxidation (only 5% through the anaerobic pathway). Once the oxygen supply is insufficient, the aerobic oxidation chain (tricarboxylic acid cycle + oxidative phosphorylation) will be immediately blocked, resulting in a “cliff-like decline” in ATP generation—Study shows that when the oxygen supply in the cerebral blood decreases by 10%, the neuron ATP level can drop by 30% within 5 minutes, directly affecting the function of the sodium-potassium pump and causing synaptic transmission disorders.

How does the imbalance in brain oxygen supply and demand trigger the “fatigue chain” during high-intensity brain activities?

When performing continuous focused brain activities (such as exam preparation, complex decision-making), the metabolic rate of cognitively related brain areas such as the prefrontal cortex and hippocampus of the brain will surge by 30%-50%:

• ·Double the demand for glucose oxidation: 1.07L of oxygen is consumed per gram of glucose to produce 38 molecules of ATP; but if the oxygen supply is insufficient, metabolism will be forced to turn to “anaerobic glycolysis”. At this time, only 2 molecules of ATP are generated per gram of glucose, accompanied by 1.8 grams of lactic acid accumulation (19 times that of aerobic metabolism).
• The “double blow” of lactic acid accumulation: ① Lactic acid reduces the pH of extracellular fluid from 7.4 to below 7.2, inhibits the release of glutamate (main excitatory transmitter) in the presynaptic membrane, resulting in a decrease in neural signal transmission speed by 20%-30% (expressed by distraction and slower response); ② Lactic acid activates microglia to release inflammatory factors (such as IL-6), further damaging the hippocampal synaptic plasticity (expressed by short-term memory loss, such as not remembering what I just read).
• Clinical data show that after 2 hours of high-intensity mental activity, the subject’s arterial oxygen saturation (SpO₂) decreased by an average of 2%-3%, and the local oxygen saturation in the prefrontal cortex (monitored by near-infrared spectroscopy) decreased by 5%-8%. At this time, the error rate for completing the same cognitive task increased by 40%, and the response time was extended by 25%.

How to accurately “break the deadlock” with 30% concentration oxygen therapy? Efficient intervention from alveoli to synapses

This oxygen generator provides an oxygen-rich gas of 30% concentration (FiO₂=30%) to achieve “targeted oxygen supplementation” through the following path:

• 1. Improve the efficiency of alveolar-blood oxygen transport: Under normal air (FiO₂=21%), the alveolar oxygen partial pressure (PAO₂) is about 104mmHg and the arterial blood oxygen partial pressure (PaO₂) is about 95mmHg; after inhaling 30% oxygen, PAO₂ can increase to 140-150mmHg, and PaO₂ can increase to 130-140mmHg (35-45mmHg).
•  Increase “instant oxygen reserve” in cerebral blood flow: oxygen in the blood exists in two forms—98% binds to hemoglobin (near saturation when the oxygen saturation reaches 97%-98%), and 2% is physically dissolved oxygen (which increases linearly with increasing PaO₂). In every 100ml of blood, physical dissolved oxygen increases by 0.03ml for every 10mmHg increase in PaO₂; when PaO₂ increases from 95mmHg to 135mmHg (40mmHg increase), dissolved oxygen can increase from 0.3ml/100ml to 0.42ml/100ml, an increase of 40%. This part of “extra dissolved oxygen” can directly pass through the blood-brain barrier (cerebral blood flow is about 750ml/min), providing a “instant oxygen source” for metabolic neurons without waiting for hemoglobin to dissociate, and it takes effect faster.
• Accelerate metabolic repair: Sufficient oxygen supply can restart the tricarboxylic acid cycle, restore the ATP generation efficiency to normal level (38ATP per molecule of glucose), provide energy for the sodium-potassium pump, and promote the normal release of glutamate in the presynaptic membrane (study shows that after 15 minutes of oxygen supplementation, the synaptic transmission efficiency can be increased by 18%-22%); at the same time, the increase in oxygen supply can activate lactate dehydrogenase, accelerate the conversion of lactic acid into pyruvate into aerobic metabolism, and reduce the lactic acid concentration in the prefrontal cortex by 25%-30% within 30 minutes, alleviating the inhibition of neural signals by the decrease in pH.

Safety and adaptability: Why is 30% concentration the optimal solution to “brain-replenishing oxygen”?

• Avoid “oxygen dependence” risk: 30% concentration is “physiological grade oxygen supplementation” (approximately the oxygen environment after the plateau), does not inhibit the oxygen sensing function of the carotid body (high concentration of oxygen > 60% may weaken respiratory drive), suitable for short-term (15-30 minutes) multiple uses per day;
• Matching the “fluctuation demand” of mental activities: The brain fatigue of students/business people is mostly “parady” (such as during exams and meetings). 30% oxygen concentration can quickly make up for the short-term oxygen gap and will not increase the brain metabolic burden (excessive oxygen concentration may induce oxidative stress).

Several studies in young people have confirmed that during the 2-hour cognitive task, 30% oxygen inhalation per hour for 15 minutes, the subject’s attention duration can be extended by 30%, working memory capacity increases by 15%, and no discomfort response – this is the professional basis for its “precision, safe, and efficient”.

In short, our oxygen generator does not “add additional brain burden”, but helps neurons maintain efficient metabolic state by supplementing the “oxygen supply gap” during high-intensity brain activities, fundamentally alleviating the fatigue chain of “hypoxia-ATP reduction-lactic acid accumulation”, making the focus and clear cognitive state easier to maintain – this is the professionalism based on the brain metabolic mechanism.